125 Mechanism of treg cells exerting antigen-specific immune suppression under UVB treatment: From patients to translational study

UVB irradiation is a commonly used therapy for inflammatory skin diseases, which has been known to attenuate immune responses partly via the induction of CD4+Foxp3+ Treg cells. accompanied by antigen immunization reported induce antigen-specific transferable However, UVB-induced cells exerting suppression not well investigated yet. The effects were studied in murine models OVA-induced inflammation and transplantation. regulatory function was tested ex vivo assay adoptive transfer experiments. expression LAG-3 on patients examined immunefluorescence. changes peripheral blood under analyzed CyTOF. did suppress mice when ablated. inhibited LPS-stimulated BMDC activation presence OVA. Adoptive experiments further confirmed their ability inflammation. prolonged allograft survival an manner. In humans, undetectable lesional with atopic dermatitis. cell population increased treated UVB. These findings suggested critical association UVB-exposed expressing immunosuppression.